Human Milk Oligosaccharides and Immune System Development

Oligosaccharides of Human Milk

Two new octasaccharides were isolated from human milk of a nonsecretor Lewis a+bindividual. Structural studies by sequential enzymic degradation and by quantitative methylation analysis revealed that their structures were as follows: Gal/31 + 3 (Fuccul + 4) GlcNAcPl + 3Gal/H -+ 4 (Fucal -+ 3) GlcNAcPl + 3Gal/31+ 4Glc, Gal/?1 + 4 (Fuccul -+ 3) GlcNAcj31 + 3Gal/31 -+ 4 (Fuccul -+ 3) GlcNAcj31 + 3...

5410 Oligosaccharides of Human Milk

Two new octasaccharides were isolated from human milk of a nonsecretor Lewis a+bindividual. Structural studies by sequential enzymic degradation and by quantitative methylation analysis revealed that their structures were as follows: Gal/31 + 3 (Fuccul + 4) GlcNAcPl + 3Gal/H -+ 4 (Fucal -+ 3) GlcNAcPl + 3Gal/31+ 4Glc, Gal/?1 + 4 (Fuccul -+ 3) GlcNAcj31 + 3Gal/31 -+ 4 (Fuccul -+ 3) GlcNAcj31 + 3...

Development of an annotated library of neutral human milk oligosaccharides.

Human milk oligosaccharides (HMOs) perform a number of functions including serving as prebiotics to stimulate the growth of beneficial intestinal bacteria, as receptor analogues to inhibit binding of pathogens, and as substances that promote postnatal brain development. There is further evidence that HMOs participate in modulating the human immune system. Because the absorption, catabolism, and...

Regulatory Aspects of Human Milk Oligosaccharides.

Human milk oligosaccharides are key components of human milk and appear in various compositions and concentrations in all human milks. In regulatory sense human milk oligosaccharides are classified as novel foods or novel food ingredients requiring safety assessment. In addition, if any health messages are intended to be used also health claim regulations apply. This chapter reviews the regulat...

Human Milk Oligosaccharides Important for Infant Defense